bioinfo-statistics

Gimeno-Valiente, F., Castignani, C., Larose Cadieux, E. et al. DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution. Nat Genet (2025). https://doi.org/10.1038/s41588-025-02307-xAbstractAberrant DNA methylation has been described in nearly all human cancers, yet its interplay with genomic alterations during tumor evolution is poorly understood. To explor..

Gabbutt, C., Duran-Ferrer, M., Grant, H.E. et al. Fluctuating DNA methylation tracks cancer evolution at clinical scale. Nature (2025). https://doi.org/10.1038/s41586-025-09374-4AbstractCancer development and response to treatment are evolutionary processes1,2, but characterizing evolutionary dynamics at a clinically meaningful scale has remained challenging3. Here we develop a new methodology c..

Bhatt, B.J., Ghosh, S., Mazurak, V. et al. Molecular subtypes of human skeletal muscle in cancer cachexia. Nature (2025). https://doi.org/10.1038/s41586-025-09502-0 AbstractCancer-associated muscle wasting is associated with poor clinical outcomes1, but its underlying biology is largely uncharted in humans2. Unbiased analysis of the RNAome (coding and non-coding RNAs) with unsupervised clus..